1987年和1998年在北极地区的亚托皮频率
Tyra Krause1, Anders Koch, Jeppe Friborg
1Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark. tgv@ssi.dk
Lancet (London, England)
|September 21, 2002
概括
1987年至1998年间,格陵兰人的阿托皮 (一种过敏状况) 发生率翻了一番. 这种阿托皮症的增加表明环境因素,而不仅仅是童年暴露,有助于其发展.
科学领域:
- 环境医学 环境医学
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 有限的客观数据存在于非工业化地区的亚托皮病患病率.
- 之前关于阿托皮频率的研究主要集中在工业化国家.
研究的目的:
- 为了确定格陵兰岛人口在11年期间的亚托皮频率的变化.
- 调查格陵兰岛阿托皮病患病率的年龄分布.
主要方法:
- 从1987年和1998年的人口查分析了859名格陵兰人15-80岁的血清样本.
- 亚托邦是由特定的免疫球蛋白E (IgE) 水平对八种常见的吸入过敏原来定义的.
- 统计分析包括计算风险比率和置信区间.
主要成果:
- 亚托皮的患病率从1987年的10%显著增加到1998年的19% (风险比1.88).
- 在包括老年人在内的各种年龄组中,观察到阿托皮频率的翻倍.
- 这种增长在15-19岁的年龄组中最为明显.
结论:
- 在格陵兰人口中,十多年来,阿托皮的患病率显著增加.
- 这些发现表明,阿托皮的危险因素可能超出了儿童早期的暴露范围.
- 需要进一步研究不同人群中对亚托皮症发展的环境影响.
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