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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

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Published on: September 7, 2013

苏格兰恶性黑色素瘤的发病率和存活率:一项流行病学研究

Rona M MacKie1, Caroline A Bray, David J Hole

  • 1Departments of Dermatology, University of Glasgow, UK. R.M.Mackie@clinmed.gla.ac.uk

Lancet (London, England)
|September 21, 2002
PubMed
概括

从1979年至1998年,黑色素瘤发病率在苏格兰显著增加,但由于早期检测了较薄的瘤,生存率有所改善. 建议采取公共卫生干预措施预防黑色素瘤.

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科学领域:

  • 皮肤病学 皮肤病学
  • 流行病学 流行病学
  • 公共卫生 公共卫生

背景情况:

  • 侵袭性原发性皮肤性恶性黑色素瘤是一个重大的健康问题.
  • 评估发病率和生存率对于公共卫生规划至关重要.

研究的目的:

  • 评估苏格兰恶性黑色素瘤的发病率和生存趋势.
  • 分析黑色素瘤诊断的人口和区域差异.
  • 确定早期检测对患者存活率的影响.

主要方法:

  • 利用了来自苏格兰黑色素瘤小组的数据,其中包括1979年至1998年期间诊断的8830名患者.
  • 分析了年龄标准化的发病率,生存率和死亡率数据.
  • 与瘤厚度和检测率相关的生存率改善.

主要成果:

  • 年龄标准化的黑色素瘤发病率在男性中增加了303%,在女性中增加了187%.
  • 五年生存率显著提高,男性从58%提高到80%,女性从74%提高到85%.
  • 生存率的改善主要归因于对较薄的黑色素瘤的诊断.

结论:

  • 对于黑色素瘤的初级和二级预防,有必要采取公共卫生干预措施.
  • 国家癌症注册表是规划和监测卫生干预措施的宝贵工具.