相关实验视频

Updated: Jul 28, 2026

Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model
06:59

Using the BLT Humanized Mouse as a Stem Cell based Gene Therapy Tumor Model

Published on: December 18, 2012

在对BLM突变异构的小鼠中增强瘤形成

Kathleen Heppner Goss1, Mary A Risinger, Jennifer J Kordich

  • 1Department of Department of Molecular Genetics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.

Science (New York, N.Y.)
|September 21, 2002
PubMed
概括

由于BLM基因突变,布鲁姆综合征使个体易患癌症. 在小鼠中BLM基因的Haploinsufficiency加速淋巴瘤和增加肠道瘤,这表明它在人类癌症风险中发挥了作用.

更多相关视频

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development11:02

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

A Minimally Invasive Method for Generating a Syngeneic Orthotopic Mouse Model of Lung Cancer07:46

A Minimally Invasive Method for Generating a Syngeneic Orthotopic Mouse Model of Lung Cancer

Published on: August 19, 2025

相关概念视频

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...