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自体抗体反应通过体质突变在生殖中心之外的进化

Jacqueline William1, Chad Euler, Sean Christensen

  • 1Department of Laboratory Medicine, Section of Immunobiology, Yale University School of Medicine, Box 208035, New Haven, CT 06520-8035, USA.

Science (New York, N.Y.)
|September 21, 2002
PubMed
概括

生殖中心不是自身免疫性疾病中B细胞突变的唯一地点. 研究人员发现,易患狼的小鼠中的脏自反应性B细胞在不同的脏区域积极突变,挑战了长期以来的假设.

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