在用抗瘤淋巴细胞进行克隆重组后的患者中,癌症回归和自身免疫
Mark E Dudley1, John R Wunderlich, Paul F Robbins
1Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20902, USA.
Science (New York, N.Y.)
|September 21, 2002
概括
使用瘤反应细胞的采用T细胞疗法导致患者的黑色素瘤回归和T细胞重组. 这种癌症治疗也导致了黑色素细胞的自身免疫破坏,显示了治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞疗法细胞疗法
背景情况:
- 转移性黑色素瘤仍然是癌症治疗的一个重大挑战.
- 瘤反应性T细胞为向癌症免疫治疗提供了潜在的途径.
- 过度表达的自衍生分化抗原是T细胞识别的目标.
研究的目的:
- 评估在转移性黑色素瘤患者中采用T细胞移植的安全性和有效性.
- 评估转移的瘤反应性T细胞的体内行为.
- 探索这种方法在治疗晚期癌症和传染病方面的潜力.
主要方法:
- 选择高度瘤反应的T细胞,准过度表达的自衍生分化抗原.
- 在T细胞转移之前的非骨髓衰变调节方案.
- 选择的T细胞通过收养转移给转移性黑色素瘤患者.
主要成果:
- 在患者中观察到转移的T细胞的持续性克隆重组.
- 转移的T细胞在体内表现出增殖,功能活性和瘤贩运.
- 实现了转移性黑色素瘤的显著回归.
- 发生了自身免疫黑色素细胞破坏的开始,表明免疫反应.
结论:
- 瘤反应性T细胞的采用转移是转移性黑色素瘤的可行方法.
- 这种治疗导致持久的T细胞反应和临床益处.
- 这种方法对治疗各种癌症和传染病,包括艾滋病毒/艾滋病,具有前景.
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