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一个新的微管不稳定实体来自于三酸库和斑马鱼胚胎查的直角合成

Ho-Sang Moon1, Eric M Jacobson, Sonya M Khersonsky

  • 1Department of Chemistry, New York University, New York, NY 10003, USA.

Journal of the American Chemical Society
|September 26, 2002
PubMed
概括

研究人员开发了一种新方法来合成三胺化合物. 这导致了使用斑马鱼胚胎查发现基于三酸的新型微管抑制剂.

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The destabilization of microtubules can occur during different stages of the microtubule lifecycle, such as nucleation or elongation. It can take place at either end of the microtubule or in the microtubule lattices as a whole. The lifespan of individual microtubules within a cell varies according to the cell type and stage of the cell cycle. During interphase, the lifespan of the microtubule is about 30 minutes, while during cell division, it is about 15 minutes. In axonal microtubules of...