相关实验视频

Updated: May 3, 2026

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

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人类表皮生长因子和受体细胞外域综合体的晶体结构

Hideo Ogiso1, Ryuichiro Ishitani, Osamu Nureki

  • 1RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi, 230-0045, Yokohama, Kanagawa, Japan.

Cell
|September 26, 2002
PubMed
概括

表皮生长因子 (EGF) 与其受体 (EGFR) 结合,触发细胞生长. 这项研究揭示了EGF-EGFR复合体的晶体结构,详细介绍了细胞信号传递所必需的独特受体二分化机制.

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Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells09:54

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

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Internal Receptors01:31

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Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

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Integrins01:10

Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Anchoring Junctions01:03

Anchoring Junctions

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Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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