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对于乳不耐受症的结构基础在乳症患者中.
Lu Shan1, Øyvind Molberg, Isabelle Parrot
1Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5025, USA.
Science (New York, N.Y.)
|September 28, 2002
概括
一种特定的质会通过抵抗消化和激活免疫细胞,引发腹性病 (一种自身免疫性肠病). 细菌酶可能提供治疗性解毒策略.
科学领域:
- 胃肠道学和免疫学
- 自免疫性疾病 自免疫性疾病
- 分子生物学分子生物学
背景情况:
- 结核病是一种常见的自身免疫性疾病,影响小肠.
- 在基因易感个体中,质暴露会引发这种疾病.
- 炎症反应的确切发起因子仍在调查中.
研究的目的:
- 为了确定胰腺炎炎炎症反应的主要发起人.
- 为了研究的稳定性,与自身抗原的相互作用和免疫性.
- 探索潜在的治疗策略,以治疗腹腔疾病.
主要方法:
- 来自谷蛋白的特定33-mer的识别和特征.
- 在体外和体内研究评估对消化蛋白酶的稳定性.
- 测试测量的活性与组织转胺酶和T细胞反应的诱导.
主要成果:
- 一个33-mer被确定为抵抗胃,胰腺和肠道蛋白酶的分解.
- 这种可以选择性地与组织转胺酶 (tissue transglutaminase) 发生反应,而转胺酶是乳清中关键的自身抗原.
- 这种强烈诱导了所有接受测试的性病患者的肠道T细胞系,并且存在于有毒的谷物中.
结论:
- 鉴定到的33-mer可能是胆固醇诱导的炎症的主要发起者.
- 它的稳定性和与组织转谷氨酶的相互作用有助于其致病性.
- 使用细菌prolyl endopeptidase的排毒表明了对乳性Spruue的潜在口服治疗方法.
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