哺乳与儿童和年轻人中阿托皮和喘的发展之间的长期关系:一项纵向研究
Malcolm R Sears1, Justina M Greene, Andrew R Willan
1Department of Medicine, McMaster University, Ontario, Hamilton, Canada. searsm@mcmaster.ca
Lancet (London, England)
|October 2, 2002
概括
哺乳不能防止儿童的亚托皮和喘;它可能会增加风险. 这项研究跟踪了新西兰出生队列,以评估与母乳养相关的长期结果.
科学领域:
- 儿科过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 流行病学 流行病学
背景情况:
- 通常建议母乳养,以预防儿童的阿托皮和喘.
- 关于母乳养对这些疾病的保护作用的现有证据是相互矛盾的.
- 这项研究调查了新西兰出生队列中母乳养和阿托皮/喘之间的长期关联.
研究的目的:
- 评估母乳养对阿托皮和喘发展的长期影响.
- 澄清有关母乳养在预防过敏和呼吸系统疾病中的作用的相互矛盾证据.
- 分析在一个明确的出生队列与延长后续的协会.
主要方法:
- 一组由1037名出生于新西兰丹尼丁的儿童 (1972-1973) 组成的队列,从婴儿期开始跟踪到26岁.
- 收集的数据包括呼吸道问卷,肺功能测试,支气管挑战和过敏皮肤测试.
- 哺乳史在幼儿时期被记录下来,结果被纵向评估.
主要成果:
- 与未母乳养儿童相比,在13至21岁的儿童中,被母乳养4周或更长时间 (49%) 的儿童对常见的过敏原 (猫,灰尘,草花粉) 产生显著更高的亚托皮率.
- 从9岁到26岁的每个评估中,母乳养的儿童报告了更高的当前喘率.
- 多因素分析,控制混因素,表明与母乳养相关的阿托皮和当前喘的几率增加.
结论:
- 哺乳似乎没有保护儿童免受发展的阿托皮和喘.
- 这些发现表明,母乳养可能会增加这些疾病的风险.
- 需要进一步的研究,以了解这种观察到的关联背后的机制.
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