大动脉狭窄的手术治疗后左心室逆转重塑:与雷宁-血管新生素系统基因表达的相关性
Thomas Walther1, Andreas Schubert, Volkmar Falk
1Universität Leipzig, Herzzentrum, Klinik für Herzchirurgie, Leipzig, Germany. walt@medizin.uni-leipzig.de
Circulation
|October 2, 2002
概括
手术治疗大动脉狭窄症可以逆转左心室缩 (LVH),并使Renin-Angiotensin系统 (RAS) 基因表达正常化. 这项研究表明,大动脉狭窄中的LVH涉及显著的RAS变化,这些变化通过手术干预而消失.
科学领域:
- 心血管生理学心血管生理学
- 分子生物学分子生物学
- 手术研究的研究.
背景情况:
- 大动脉狭窄导致左心室缩 (LVH),这种情况通常在手术干预后逆转.
- 氨酶系统 (RAS) 在心血管重塑和功能中起着至关重要的作用.
- 了解LVH期间RAS基因表达变化及其逆转对于治疗见解至关重要.
研究的目的:
- 在外科手术诱导的左心室缩 (LVH) 和其随后的逆转的背景下调查Renin-Angiotensin系统 (RAS) 基因的表达.
- 为了确定对大动脉狭窄的手术治疗是否会影响RAS基因表达模式.
主要方法:
- 在成长中的绵羊经历了大动脉带带,以诱导受控的LVH,随后进行手术释放.
- 在整个研究过程中记录了血液动力学测量.
- 减量杂交和定量聚合酶链反应 (PCR) 用于测量血管素转化酶 (ACE),血管素受体1 (AT1-R) 和血管素受体2 (AT2-R) 的mRNA表达水平.
主要成果:
- 手术大动脉带带显著增加左心室质量指数和心肌纤维直径,证实LVH的成功诱导.
- 在LVH期间,基因表达分析显示了ACE,AT1-R和AT2-RmRNA水平的显著变化.
- 在手术释放后,左心室质量和纤维直径回归到基线水平,同时ACE和AT1-R表达显著下降,并恢复到基线AT2-R表达.
结论:
- 与大动脉狭窄相关的左心室缩伴随着在Renin-Angiotensin系统的实质性变化.
- 手术干预有效地促进反向重塑,并导致RAS基因表达的回归,这表明RAS活性和LVH逆转之间存在联系.
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