一个部分的后部无缘整形环能否防止急性缺血性 mitrale 吐?
Tomasz A Timek1, Paul Dagum, David T Lai
1Department of Cardiovascular Surgery, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif., USA.
Circulation
|October 2, 2002
概括
一个部分灵活的结婚整形环有效地预防了羊模型中的急性缺血性 mitrale 吐. 这种新的方法保持了正常的环状功能,提供了比完整的环更有可能的生理修复.
科学领域:
- 心血管外科心血管外科
- 生物医学工程 生物医学工程
- 动物模型 动物模型
背景情况:
- 在绵羊模型中,急性后侧缺血导致缺血额头吐 (IMR).
- 完整的结婚整形环可以防止IMR,但部分环可能提供更多的生理修复,在IMR动物模型中仍然未经测试.
研究的目的:
- 在羊模型中评估部分柔性结婚整形环在预防急性缺血性 mitrale regurgitation (IMR) 的有效性.
- 为了比较部分环与无环在急性缺血期间对状环状动态的影响.
主要方法:
- 13只绵羊在左心室, mitra annulus 和传单上进行了放射性不透明标记的放置.
- 7只羊作为对照,6只收到了圣犹大裁部分柔性戒指.
- 动物被使用视频光学和心声学研究,在动脉气球封闭引起的急性缺血之前和期间.
主要成果:
- 对照组在缺血期间表现出额头管的显著增加 (0.0至2.1),而Tailor环组没有显著变化 (0.1).
- 泰勒环限制了额头环环面积的变化 (5%vs17%),并防止了缺血期间的环环扩张.
- 使用Tailor环保持正常的环形曲,与使用完整环的观测不同.
结论:
- 在这个羊模型中,圣犹大裁的部分结婚整形环有效地预防了急性缺血腹吐.
- 这种预防可能是由于在缺血期间限制隔膜侧面直径扩张.
- 在这种急性IMR模型中,一个部分的,灵活的后部结婚术环显示出与完整环相美的有效性.
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