与MicroMed DeBakey VAD相关的血栓形成的治疗使用复合组织等离子体激活剂
Markus Rothenburger1, Markus J Wilhelm, Dieter Hammel
1Department of Thoracic and Cardiovascular Surgery, University-Hospital Muenster, Germany. markus.rothenburger@thgms.uni-muenster.de
Circulation
|October 2, 2002
概括
重组组织等离子体激活剂 (rt-PA) 在MicroMed DeBakey左心室辅助器件中有效治疗血栓形成,恢复功能并避免手术. 这种疗法可以改善患有螺旋的患者的设备性能.
科学领域:
- 心血管工程 心血管工程
- 生物医疗设备 生物医疗设备
- 血栓形成研究研究
背景情况:
- 最新的左心室辅助装置 (LVAD) 使用非脉动式螺旋.
- 在这些中形成血栓会损害流动,但通常可以避免末端器官损伤.
- 这项研究解决了MicroMed DeBakey LVAD中与血栓相关的功能障碍.
研究的目的:
- 为了评估复合组织等离子体激活剂 (rt-PA) 在治疗与血栓相关的功能障碍中的疗效,在MicroMed DeBakey LVADs.
- 为了确定rt-PA是否可以防止需要紧急外科干预.
主要方法:
- 八名患有MicroMed DeBakey LVADs的患者因疑似血栓而经历了减少的流量.
- 治疗包括静脉注射100毫克rt-PA.
- 监测了流量和功率需求,以评估治疗反应.
主要成果:
- 在rt-PA溶解后,所有八名患者都显示出改善的流量和减少的功率需求.
- 没有观察到严重的出血并发症;四名患者有过渡性表.
- 患者在血栓消毒后治疗后从重症监护室出院.
结论:
- 静脉rt-PA溶解在驱动LVAD中高效地管理与血栓相关的功能障碍.
- 这种治疗策略往往可以避免需要紧急的手术更换.
- Rt-PA为LVAD血栓形成提供了一种最小侵入性的解决方案.
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