缩改善和机械重同步不需要在扩张失败的心脏与左束分支块的电同步
Christophe Leclercq1, Owen Faris, Richard Tunin
1Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Md, USA.
Circulation
|October 3, 2002
概括
机械重同步,而不是电气同步,改善心脏功能,在左捆支部阻塞 (LBBB) 患者. 节奏的好处来自于协调的肌肉运动,增强失败的心脏的收缩功能.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 心脏电生理学 心脏电生理学
背景情况:
- 左束枝阻塞 (LBBB) 损害了心力衰竭患者的缩功能.
- 双心室 (BiV) 和左心室 (LV) 节奏改善功能,但电同步的作用尚不清楚.
研究的目的:
- 为了研究是否电同步是必要的机械同步和功能改善从节奏在LBBB失败的心脏.
主要方法:
- 在诱导LBBB的狗中利用心上图谱,标记MRI和血液动力学测量.
- 对比右心房,LV和BiV节奏对电动激活,机械重同步和心脏功能的影响.
主要成果:
- 与LBBB中的心房节奏相比,BiV和LV节奏都显著改善了心脏血液动力学.
- 节奏诱导的功能改善与机械重同步相关联.
- BiV节奏降低了电散,而LV节奏增加了电散.
结论:
- 实现机械同步并从步调中获得功能上的好处不需要电气同步.
- 机械协调是 LBBB 心脏在 BiV 或 LV 节奏期间抽缩改善的主要驱动因素.
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