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口服结合性马性雌激素和透皮雌激素替代疗法的不同影响,影响了绝经后妇女中低密度脂蛋白颗粒的大小和氧化敏感性.

Akihiko Wakatsuki1, Yuji Okatani, Nobuo Ikenoue

  • 1Department of Obstetrics and Gynecology, Kochi Medical School, Kochi, Japan. wakatuki@kochi-ms.ac.jp

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|October 3, 2002
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概括

透皮雌激素替代疗法 (ERT) 通过降低甘油三和增加LDL颗粒大小来保持雌激素的抗氧化作用. 然而,口服ERT会增加甘油三和减少LDL的大小,抵消其益处.

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科学领域:

  • 内分泌学 在内分泌学.
  • 心血管科学 心血管科学
  • 脂质代谢 脂质代谢是什么

背景情况:

  • 雌激素替代疗法 (ERT) 具有对LDL颗粒有益的抗氧化特性.
  • 口服ERT可以增加血甘油三,可能减少LDL粒子大小并否定抗氧化作用.
  • 透皮ERT可以避免甘油三的增加,保持LDL粒子大小和抗氧化功效.

研究的目的:

  • 调查通过皮肤的ERT是否可以减轻口服ERT对LDL颗粒大小和氧化的不良影响.
  • 为了比较口服与透皮ERT对绝经后妇女的LDL特征的影响.

主要方法:

  • 绝经后的妇女被分配给没有治疗,口服结合性马类雌激素或通过皮肤输出的雌激素3个月.
  • 测量了血脂质,LDL粒子直径和LDL对氧化敏感度 (TBARS测定).
  • 统计分析将LDL直径的变化与甘油三和TBARS水平相关联.

主要成果:

  • 口服ERT增加了血甘油三和降低了LDL直径,而不会影响LDL氧化.
  • 透皮ERT降低了血甘油三和LDL衍生的TBARS,并增加了LDL直径.
  • 增加的LDL直径与降低的血甘油三和LDL氧化相关.

结论:

  • 通过皮肤进行的ERT,与口服ERT不同,降低了血甘油三,产生了更大,耐氧化的LDL颗粒.
  • 透皮ERT有效地保留了雌激素在绝经后妇女的抗氧化益处.