尿中的白蛋白分泌预测了一般人群中心血管和非心血管死亡率
Hans L Hillege1, Vaclav Fidler, Gilles F H Diercks
1Trial Coordination Center, Department of Cardiology, University Hospital of Groningen, Groningen, The Netherlands.
Circulation
|October 3, 2002
概括
在一般人群中,尿中的白蛋白分泌量增加预测了全因死亡率. 较高水平与心血管和非心血管死亡有关,即使在正常的白蛋白尿范围.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 在一般人群中尿分泌量升高的临床意义仍在研究中.
- 尿中的白蛋白度 (UAC) 是各种健康结果的潜在生物标志物.
研究的目的:
- 为了研究尿路白蛋白分泌与全因死亡率之间的关联.
- 确定UAC与一般人群中心血管 (CV) 和非CV原因的死亡率之间的关系.
主要方法:
- 一项包括40,548名年龄在28-75岁之间的参与者在荷兰格罗宁根的队列研究.
- 通过邮政问卷收集的关于心血管风险因素的数据以及用于测量UAC的早晨尿样.
- 通过市政登记和国家统计数据追踪生命状况和死亡原因,平均随访时间为961天.
主要成果:
- 在增加UAC和死亡率之间观察到一种积极的剂量反应关系.
- 较高的UAC与心血管和非心血管死亡风险增加有关,独立于其他心血管风险因素.
- 在UAC中增加2倍与心血管死亡率的1.29相对风险和非心血管死亡率的1.12相对风险相关.
结论:
- 尿中的白蛋白分泌是一般人群中所有原因死亡率的预测指标.
- 增加的死亡风险主要与心血管原因有关.
- 这种关联甚至在目前被认为在正常范围内的白蛋白尿水平上也很明显.
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