Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

64.7K
Overview
64.7K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.5K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

3.0K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
3.0K
Tissue Transplantation01:24

Tissue Transplantation

1.4K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.4K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.5K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Dynamic alterations in the irradiated draining lymph node.

NPJ precision oncology·2026
Same author

Myocardial Immune Niches in Homeostasis and Inflammation.

Immunological reviews·2026
Same author

PMGen: from peptide-MHC structure prediction to peptide generation.

Bioinformatics (Oxford, England)·2026
Same author

IL-33-induced ILC2 effector cytokine responses promote the expansion of red pulp macrophages.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches.

Immunity·2026
Same author

Selective elimination of circulating effector CD8 T cells via LTβR blockade separates anti-CD137 efficacy from toxicity.

Science advances·2026

相关实验视频

Updated: Apr 30, 2026

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

13.2K

移植动脉样硬化病变中的光滑肌肉细胞起源于接受者,但不是骨髓原始细胞.

Yanhua Hu1, Fergus Davison, Burkhard Ludewig

  • 1Institute for Pathophysiology, University of Innsbruck Medical School, Innsbruck, Austria.

Circulation
|October 3, 2002
PubMed
概括

移植动脉样硬化病变中的光滑肌肉细胞来自接受者,而不是捐赠器. 这项研究表明,非骨髓前代细胞是这些光滑肌肉细胞的可能来源.

更多相关视频

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

8.1K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

7.7K

相关实验视频

Last Updated: Apr 30, 2026

Mouse Models for Graft Arteriosclerosis
07:37

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

13.2K
Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

8.1K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

7.7K

科学领域:

  • 血管生物学 血管生物学
  • 移植免疫学 移植免疫学
  • 细胞生物学 细胞生物学

背景情况:

  • 在血管内的光滑肌肉细胞 (SMC) 积累是移植动脉样硬化的核心.
  • 这些病变中的SMCs的起源,传统上被认为来自捐赠媒介,是有争议的.

研究的目的:

  • 用小鼠全移植模型阐明移植动脉样硬化中SMCs的细胞起源.
  • 为了确定新生和动脉样硬化病变中的SMC是否来自供体或受体来源.

主要方法:

  • 使用转基因小鼠 (ROSA26,SM-LacZ) 和骨髓移植模型.
  • 对beta-galactosidase (gal) 表达进行分析,以追踪细胞系.
  • 研究了骨髓细胞在体外分化的潜力,将其转化为SMC.

主要成果:

  • 移植中的新阴性细胞仅来自宿主 (受体) 细胞.
  • 在不同转基因模型中,病变中的SMC始终来自接受者,而不是捐赠者血管.
  • 骨髓移植显示出有限的贡献,但骨髓细胞在体外显示出SMC分化潜力.

结论:

  • 提供了强有力的证据,即受体细胞是所有移植动脉样硬化病变中SMC的来源.
  • 表明非骨髓衍生的前代细胞是这些病变中SMC的潜在来源.