在基本高血压中,中度饮食限制的短期和长期神经上腺作用
Guido Grassi1, Raffaella Dell'Oro, Gino Seravalle
1Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Università Milano-Bicocca, Centro Interuniversitario di Fisiologia Clinica e Ipertensione and Istituto Auxologico Italiano, Milan, Italy.
Circulation
|October 9, 2002
概括
在基本高血压中适度的限制增加了交感神经活动,并损害了巴罗反射功能. 这些不良影响在长期的低饮食中持续存在,突出显示了饮食中减少的风险.
科学领域:
- 心血管生理学心血管生理学
- 高血压研究 高血压研究
- 神经内分泌学神经内分泌学
背景情况:
- 基本高血压通常与交感神经系统失调有关.
- 短期严重的限制可以急剧增加肌肉交感神经流量 (MSNA),并损害腹部反射.
研究的目的:
- 在患有基本高血压的患者中研究中度饮食限制的长期神经上腺和反射效应.
主要方法:
- 11名患有轻度至中度基本高血压的患者接受了血压,心率和MSNA的测量.
- 在定期摄入时进行测量,在1周的低饮食 (80 mmol NaCl/d) 后,在8周的相同饮食后进行测量.
主要成果:
- 一周的低饮食增加了23%的血雷宁活性,阿尔多和MSNA,同时减少了47%的MSNA的巴罗反射调节.
- 这些神经幽默和呼吸反射变化在8周内持续存在,并在恢复正常饮食后恢复正常.
结论:
- 适度的饮食限制诱导了同情激活和巴罗反射障碍在基本高血压.
- 持续几周的低饮食并不能缓解这些有害的神经上腺和反射变化.
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