基于聚甲烯酸的氧化捐赠体的合成和特征
Pawel G Parzuchowski1, Megan C Frost, Mark E Meyerhoff
1Department of Chemistry, The University of Michigan, Ann Arbor, Michigan 48109-1055, USA.
研究人员开发了一种新方法,从甲烯材料中制造释放氧化 (NO) 的聚合物. 这些先进的聚合物可用于制造用于扩展治疗应用的无释放微珠.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 氧化 (NO) 在生理过程中起着至关重要的作用.
- 开发能够控制NO释放的材料具有重要的治疗意义.
- 基于甲基酸盐的聚合物为材料功能化提供了多功能平台.
研究的目的:
- 合成新型甲基酸同型和共聚物,其功能与二次氨基群.
- 为了将这些氨基组转化为释放氧化 (NO) 的N-diazeniumdiolates.
- 调查NO释放动力学和创造NO释放聚合物微珠的潜力.
主要方法:
- 玻璃保护甲酸单体的多步合成.
- 由氧化启动的自由基聚合.
- 氨酸脱保护和随后的反应与NO和甲氧化物.
- 聚合物分子重量和成分的表征.
- 使用二甲酸交叉连接器进行悬浮聚合,用于微珠形成.
主要成果:
- 成功合成了分子重量高达2.58 x 10^6 Da 的甲酸聚合物.
- 从N-diazeniumdiolated聚合物中获得持续的NO释放,明显半衰期为30-60分钟.
- 已证明NO负载和释放高达1.99微摩尔/毫克,与氨基含量成比例.
- 制造的甲基酸盐微珠 (100-200微米),能够在现场释放NO.
结论:
- 为释放NO的甲酸聚合物和微珠建立了一条可行的合成途径.
- 合成的材料表现出受控和持续的氧化释放.
- 开发的聚合物和微珠对需要局部NO输送的应用具有前景.
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