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相关概念视频

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...

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相关实验视频

Updated: Jul 9, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

罗斯曼和谢克曼被拉斯克指控贩运人口.

Vivek Malhotra1, Scott D Emr

  • 1Department of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093, USA. malhotra@biomail.ucsd.edu

Cell
|October 10, 2002
PubMed
概括

詹姆斯·罗斯曼 (James Rothman) 和兰迪·谢克曼 (Randy Schekman) 获得了拉斯克奖,因为他们对膜交通机制的突破性研究. 他们的工作大大提高了我们对细胞如何运输必需分子的理解.

科学领域:

  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学
  • 生物化学 生物化学

背景情况:

  • 细胞过程依赖于分子在膜结合区内的精确运输.
  • 功能障碍的膜流量与许多疾病有关,包括神经系统疾病和代谢疾病.

研究的目的:

  • 为了表彰詹姆斯·罗斯曼和兰迪·谢克曼对理解膜交通的开创性贡献.
  • 阐明控制囊泡运输和融合的分子机械.

主要方法:

  • 这项研究涉及酵母中的基因分析和哺乳动物细胞中囊泡运输的生物化学重构.
  • 确定了调节囊泡芽,向和融合的关键蛋白质和途径.

主要成果:

  • 罗斯曼和谢克曼确定了囊泡介导运输的分子参与者和调节原则.
  • 他们的工作揭示了囊泡如何与目标膜接和融合,确保细胞货物的准确传递.

结论:

  • 罗斯曼和谢克曼的发现为蜂物流提供了一个基本的框架.
  • 这项研究对了解健康和疾病有深远的影响,为治疗干预打开了道路.

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Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS)
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Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS)

Published on: April 18, 2018

Shotgun Lipidomics of Rodent Tissues
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Shotgun Lipidomics of Rodent Tissues

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相关实验视频

Last Updated: Jul 9, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
12:02

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Published on: November 2, 2016

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS)
09:58

Spatial Quantification of Drugs in Pulmonary Tuberculosis Lesions by Laser Capture Microdissection Liquid Chromatography Mass Spectrometry (LCM-LC/MS)

Published on: April 18, 2018

Shotgun Lipidomics of Rodent Tissues
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Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022