大心 Amyloidosis:持续性心房动的一个心律失常基质
Christoph Röcken1, Brigitte Peters, Gina Juenemann
1Department of Pathology, Otto-von-Guericke-University, Magdeburg, Germany. christoph.roecken@medizin.uni-magdeburg.de
Circulation
|October 16, 2002
概括
隔离性心房粉症 (IAA) 是心房动 (AF) 的显著预测因子,独立于年龄和性别. 这一发现表明IAA增加了AF风险,并可能影响心房纤维化治疗策略.
科学领域:
- 心脏病学 心脏病学
- 病理学 病理学 病理学
- 电子生理学 电子生理学
背景情况:
- 心房纤维化是心房动 (AF) 的已知危险因素.
- 隔离性心房粉样化症 (IAA) 在AF发病过程中的作用尚不清楚.
研究的目的:
- 调查IAA与AF存在之间的关联.
- 确定IAA是否是AF的独立预测因素.
主要方法:
- 从245名接受开放心脏手术的患者中分析了右心房附属体.
- 使用刚果红色染色和免疫组织化学识别和分类心房粉样蛋白.
- 粉样蛋白存在与临床因素的相关性,包括年龄,性别,门疾病和AF史.
主要成果:
- 在16.3%的患者中发现了心房粉样蛋白,所有这些患者对心房 natriuretic (ANP) 具有免疫反应.
- 粉样蛋白的存在与年龄,P波持续时间,性别,门疾病和AF显著相关.
- IAA被确定为AF的唯一独立于年龄和性别的预测因子.
- 在IAA和心房纤维化之间观察到显著的反相关性.
结论:
- 隔离性心房粉症 (IAA) 导致心房传导异常,并增加患心房的风险.
- 年龄是IAA发展的关键因素,可能形成一个粉样核.
- 病理状况,如门疾病,通过影响ANP水平,影响IAA的进展.
- IAA和心房纤维化之间的反向关系表明,在这些患者中,ACE抑制剂的有效性可能受到限制.
相关概念视频
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Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
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Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
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