丸激素降低了多菲提利德对正常雌性子的前节律效应
Thai V Pham1, Eugene A Sosunov, Evgeny P Anyukhovsky
1Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Fla, USA.
5alpha-dihydrotestosterone (DHT) 保护雌性子免受反极化延长药物的影响. 升高的DHT水平降低了药物效应和脱极化后,表明对抗心律失常的雄激素保护.
科学领域:
- 心血管药理学心血管药理学
- 内分泌学 在内分泌学.
- 心脏电生理学 心脏电生理学
背景情况:
- 及其代谢物5alpha-dihydrotestosterone (DHT) 可能会对男性的复极延长药物提供保护.
- 这项研究调查了DHT是否能保护正常雌性子免受药物诱导的过度复极化延长.
研究的目的:
- 为了测试5alpha-dihydrotestosterone (DHT) 保护正常女性免受药物诱导的反极化过度延长的假设.
- 为了确定DHT是否会影响雌性子中多菲提利德的电生理效应.
主要方法:
- 微电极技术被用来研究隔离的子心室内脏.
- 雌性子被用DHT治疗了4周,并测量了血清激素水平.
- 评估了对dofetilide的反应中的90%再极化 (APD90) 和早期脱极化后的动作潜能持续时间.
主要成果:
- 与对照女性相比,接受DHT治疗的女性的基础APD90较短.
- 在接受DHT治疗的女性中,多菲提利德诱导的APD90的增加明显较小.
- 在接受DHT治疗的女性中,在多菲提利德度较高的情况下,早期脱极化后的发病率较低.
结论:
- 提高DHT水平可以降低多菲提利德在雌性子中的前节律效应.
- DHT治疗导致了与正常男性观察到的类似的电生理学参数.
- 这些发现表明,DHT和潜在的其他雄激素可能会保护女性免受多菲提利德诱导的心律失常.
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