细胞染色体P450的临床重要性
Daniel W Nebert1, David W Russell
1Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267-0056, USA. dan.nebert@uc.edu
Lancet (London, England)
|October 22, 2002
概括
人类细胞染色体P450 (CYP) 超级家族,包括57个基因,对于代谢药物和内源化合物至关重要. 功能障碍的CYP基因与代谢和各种疾病的先天性错误有关.
科学领域:
- 生物化学 生化学
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
背景情况:
- 人类细胞染色体P450 (CYP) 超级家族由57个基因组成.
- CYP酶参与各种代谢途径,包括药物,类固醇和维生素.
- 以前被视为主要是肝脏药物排毒系统,CYP的作用现在被理解为更广泛,包括重要生命过程.
研究的目的:
- 为了提供人体细胞染色体P450 (CYP) 超级家族的概述.
- 要突出CYP酶在药物代谢之外的多样性功能.
- 为了强调CYP基因突变的临床意义.
主要方法:
- 对CYP超级家族功能的文献综述.
- 分析已知的CYP基因在各种代谢途径中的作用.
- 检查CYP基因变异的临床影响.
主要成果:
- CYP基因编码了对代谢药物,外来化学物质,阿拉基酸,eicosanoids,胆固醇,胆汁酸,类固醇和维生素D3至关重要的酶.
- 此外,CYP酶在视网膜酸化和其他功能中也起作用.
- CYP基因的突变与代谢的先天性错误和临床相关疾病有关.
结论:
- 人类CYP超级家族对于许多生理过程至关重要.
- 了解CYP酶功能对于理解药物相互作用和代谢障碍至关重要.
- CYP基因突变对人类疾病病理学有重大贡献.
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