神经和免疫学突触关系的神经和免疫学突触关系
Michael L Dustin1, David R Colman
1Program in Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016 USA. dustin@saturn.med.nyu.edu
概括
突触是细胞结点,可以通过神经和免疫系统的分泌物进行信息传输. 它们的结构包括分泌和粘附领域的活性区域,表面分子调节功能.
科学领域:
- 细胞生物学 细胞生物学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 突触是专门的细胞结点,对于细胞间通信至关重要.
- 神经系统和免疫系统都使用突触来提供有针对性的信号.
- 突触结构的特点是分泌和周围粘附领域的活跃区域.
研究的目的:
- 描述突触的基本结构和功能.
- 突出突出突触在神经和免疫系统中的作用.
- 讨论表面分子对突触功能的影响.
主要方法:
- 审查关于突触结构和功能的现有文献.
- 在突触微域内分析分子组件.
- 对不同类型细胞中突触机制的比较研究.
主要成果:
- 突触通过受控分泌促进信息中继.
- 微域结构包括中央活性区和外围粘附域.
- 表面分子是调节突触活动的组成部分.
结论:
- 突触是不同生物系统中保存的信号平台.
- 突触的结构组织是它们功能特异性的基础.
- 突触功能的调节是通过动态分子相互作用来实现的.
相关概念视频
Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
The Synapse
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Overview of Synapses
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
Integration of Synaptic Events
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...


