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口服的Everolimus抑制了支架内新极端的生长
Andrew Farb1, Michael John, Eduardo Acampado
1Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Circulation
|October 31, 2002
概括
口服Everolimus有效地降低了子腹动脉内置支架的neointimal生长. 这项研究表明,口服Everolimus的使用会导致显著的新极限愈合和内皮质化,这是一种有前途的治疗方法.
科学领域:
- 心血管研究研究心血管研究
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 拉帕米辛 (sirolimus) 释放的支架在减轻缩症方面表现有前途.
- 埃弗罗利斯是一种与西罗利斯相关的宏类药物,研究了它对新极端生长的影响.
研究的目的:
- 评估口服埃弗罗利斯在抑制静脉支架内新极端生长方面的疗效.
- 在子 iliac 动脉模型中评估口服 everolimus 治疗的安全性和治疗特性.
主要方法:
- 新西兰的白接受了口服常利的不同剂量或安慰剂.
- 在关动脉中植入了支架,动物接受了28天的治疗.
- 评估了新极端生长,支架支架覆盖范围和内皮质化.
主要成果:
- 两组Everolimus治疗群体都显示出实体内新极体生长显著减少 (46%和42%).
- 第二组 (1.5毫克/千克,然后0.75毫克/千克) 显示愈合的neointima与>80%的支架表面内皮化.
- 在较低剂量方案中,口服everolimus被很好地容忍,没有副作用.
结论:
- 口服的everolimus有效地抑制了子 iliac动脉中的内置支架的neointimal生长.
- 一种特定的剂量方案 (1.5毫克/千克,然后0.75毫克/千克) 耐受良好,并促进了新极端的愈合和内皮质化.
- 口服Everolimus是一种潜在的治疗策略,可以预防支架后的缩.
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