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帕帕因酸酸酶活性的蛋白质工程:对突变和野生类型酶的分子动力学研究

Swarnalatha Y Reddy1, Kalju Kahn, Ya-Jun Zheng

  • 1Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, California 93106, USA.

Journal of the American Chemical Society
|October 31, 2002
PubMed
概括

分子动力学模拟揭示了 papain 的 Gln19Glu 突变物如何催化化. 该研究确定了关键的结相互作用和接近攻击的适配体,突出了Glu19在一般酸催化中的作用.

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