体体:由体颗粒组成的选择性透囊
A D Dinsmore1, Ming F Hsu, M G Nikolaides
1Department of Physics and DEAS, Harvard University, Cambridge, MA 02138, USA. dinsmore@physics.umass.edu
Science (New York, N.Y.)
|November 2, 2002
概括
研究人员开发了一种方法来制造空洞的弹性囊,称为体体. 这些多功能结构可以精确控制尺寸,透性和强度,在细胞免疫隔离中具有潜在的应用.
科学领域:
- 材料科学与工程 材料科学与工程
- 合体和接口科学科学
- 生物材料工程 生物材料工程
背景情况:
- 制造具有可调节性质的微囊仍然是材料科学中的一个重大挑战.
- 现有的方法往往缺乏精确控制外的特性,如透性和机械强度.
- 对于从药物输送到细胞封装的应用来说,需要强大的,可控制的封装系统至关重要.
研究的目的:
- 开发一种新的制造方法,用于制造具有精确控制性能的固体囊.
- 为了研究状颗粒的自我组装,以形成外.
- 为了证明制造结构的多功能性和潜在应用,称为体体.
主要方法:
- 在乳液滴的接口上利用了合粒的自我组装.
- 锁定组装的粒子在乳液核心周围形成弹性外.
- 将结果的体体转移到匹配的连续相流体中,以确保结构完整性.
主要成果:
- 成功地制造出空洞,弹性外 (结合体),精确控制尺寸,透性和机械强度.
- 使用各种溶剂,体颗粒和封装内容物证明了该方法的通用性.
- 展示了体体的强度及其对细胞免疫隔离的潜力.
结论:
- 自组装方法为制造工程微囊 (合体) 提供了一个多功能和强大的平台.
- 体体具有可调节的特性,可以在各种科学和技术领域进行定制的应用.
- 证明了细胞免疫隔离的潜力,凸显了这种制造技术在生物医学应用中的重要性.
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