由转变寄生虫Theileria劫持宿主细胞IKK信号体
Volker T Heussler1, Sven Rottenberg, Rebekka Schwab
1Division of Molecular Pathology, Institute of Animal Pathology, University of Bern, CH-3012 Bern, Switzerland.
概括
泰利利亚寄生虫通过激活核因子卡帕B (NF-kappaB) 信号来劫持宿主细胞. 这涉及IkappaB激酶 (IKK) 复合体在寄生虫表面的组合,这对感染细胞的生存至关重要.
科学领域:
- 寄生虫学的寄生虫学
- 蜂信号传输是如何进行的
- 免疫学 免疫学 免疫学
背景情况:
- 寄生虫采用各种策略来确保生存和逃避宿主防御.
- 细胞内原生虫寄生虫Theileria独特地诱导不受控制的宿主细胞增殖.
- 细胞转化白细胞需要持续的核因子kappa B (NF-kappaB) 活性才能生存.
研究的目的:
- 阐明Theileria寄生虫操纵宿主细胞信号的机制.
- 调查IkappaB激酶 (IKK) 在Theileria诱导的宿主细胞转化中的作用.
- 了解病原体如何破坏宿主细胞传播途径.
主要方法:
- 免疫光显微镜可视化蛋白质定位.
- 生物化学试验用于研究蛋白质复合体组合.
- 对Theileria寄生虫阶段 (schizont和 merozoite) 的分析.
主要成果:
- 在Theileria转换的白细胞中,构成NF-kappaB活动是由IKK招募的介导.
- 该IKK信号体特别聚集在寄生虫表面的大型激活焦点中.
- IKK信号体组合是特定阶段的,在转化性分裂体中观察到,但在非转化性 merozoites 中降低.
结论:
- 泰利里亚寄生虫通过将IKK复合物招募到它们的表面来颠覆宿主细胞信号.
- 这种向的IKK激活对于维持受感染白细胞的增殖至关重要.
- 了解这种机制可以了解病原体与宿主相互作用和信号通路操纵.
相关概念视频
Translocation of Proteins into the Mitochondria
Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Intracellular Signaling Affects Focal Adhesions
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
American Trypanosomiasis
Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...


