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将Fanconi的贫血与乳腺癌的倾向性联系起来

Ashok R Venkitaraman1

  • 1CR UK Department of Oncology, University of Cambridge, and Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, CB2 2XZ, Cambridge, UK. arv22@cam.ac.uk

Lancet (London, England)
|November 9, 2002
PubMed
概括

No abstract available in PubMed .

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Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...