在成年人视觉皮层中重新激活眼睛主导性可塑性
Tommaso Pizzorusso1, Paolo Medini, Nicoletta Berardi
1Scuola Normale Superiore, 56100 Pisa, Italy. tommaso@in.pi.cnr.it
Science (New York, N.Y.)
|November 9, 2002
概括
在成年大鼠中,在细胞外基质 (ECM) 中降解的里丁硫酸盐蛋白质糖 (CSPG) 重新激活视觉皮质的可塑性,使单眼剥夺后的眼睛主导转移成为可能,这表明成熟的ECM抑制了体验依赖的变化.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 细胞外矩阵生物学 细胞外矩阵生物学
背景情况:
- 在年轻动物中,单眼剥夺会诱导眼睛主导的转移,但在成年人中,在临界后期,这种情况并非如此.
- 氏素硫酸蛋白质糖 (CSPGs),细胞外基质 (ECM) 组成部分,抑制轴突芽发.
- 在限制经验依赖的可塑性方面,ECM成熟的作用仍然不清楚.
研究的目的:
- 调查ECM的发育成熟是否抑制成人视觉皮层的经验依赖可塑性.
- 确定CSPG降解是否可以恢复成人视觉皮层中的可塑性.
主要方法:
- 评估了与关键时期有关的CSPG组织成周神经网络.
- 利用暗色养来研究ECM成熟时间.
- 在成年大鼠视觉皮层中,给予冠状腺酶-ABC来降解CSPG.
- 在成年大鼠治疗后引起的单眼剥夺.
主要成果:
- CSPG组织成周神经网络与关键时期的结束相吻合,而这被黑暗的养所推迟.
- 在成年大鼠中使用冠状腺酶-ABC降解CSPG,使单眼剥夺后的眼睛主导转变成为可能.
- 在CSPG退化后,眼睛主导地位的转变有利于非剥夺的眼睛.
结论:
- 成熟的细胞外基质 (ECM),特别是CSPG,在成年视觉皮层中起到抑制性障碍,阻碍体验依赖的可塑性.
- CSPGs的降解可以在成年动物中重新激活或恢复皮质可塑性.
- 这些发现强调了ECM在调节关键期可塑性的作用,并表明了ECM调制的治疗潜力.
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