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相关实验视频

Updated: Jul 16, 2026

The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
10:15

The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits

Published on: August 20, 2014

塑化剂从血液透析输血管中迁移. 关于初步报告的初步报告

K Ono, R Tatsukawa, T Wakimoto

    JAMA
    |December 1, 1975
    PubMed
    概括

    在血液透析过程中,二二乙基基酸盐从聚乙烯化物血液输送到患者血液中泄露出来. 这项研究确定了增塑剂的迁移,促使人们需要更安全,无可提取的医疗管道材料.

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    科学领域:

    • 医疗器械材料科学科学 医疗器械材料科学
    • 临床化学 临床化学
    • 腎臟病學 (nephrology) 是一種醫學專業.

    背景情况:

    • 聚乙烯 (PVC) 是医疗器械中常见的材料,包括血液管道.
    • 人们担心,PVC中的增塑剂可能会被出到生物液体中.
    • 血液透析涉及血液和医疗管道之间的长时间接触.

    研究的目的:

    • 为了研究二二乙甲甲酸盐 (DEHP) 从PVC血液管中迁移到人体血液中.
    • 在接受血液透析的患者中评估DEHP的存在.

    主要方法:

    • 从血液透析患者的血液样本的分析.
    • 检测和定量二-2-乙基基甲酸盐.

    主要成果:

    • 检测到di-2-ethylhexylphthalate从pvc输血管迁移到16名末期功能衰竭患者的血液中.
    • 在研究阶段的研究队列中没有观察到有毒效应.

    结论:

    • 在血液透析过程中,PVC血管可以将二-2-乙基基甲酸释放到患者的血液中.
    • 建议开发一种没有可提取材料的替代性塑料管,以提高患者的安全性.

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    Last Updated: Jul 16, 2026

    The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
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    The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits

    Published on: August 20, 2014

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    Published on: May 30, 2019