饮食和运动干预对血压,胰岛素,氧化应激和氧化可用性的影响
Christian K Roberts1, Nosratola D Vaziri, R James Barnard
1Department of Physiological Science, University of California, Los Angeles 90095-1527, USA.
Circulation
|November 13, 2002
概括
3周的饮食和运动干预显著改善了血压,胰岛素抵抗和氧化 (NO) 的可用性,降低了动脉样硬化风险.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 营养科学 营养科学
背景情况:
- 饮食和运动是已知调节血压和动脉样硬化风险的因素.
- 了解特定干预措施的影响对于预防心血管疾病至关重要.
研究的目的:
- 为了研究短期,严格的饮食和运动方案的影响.
- 评估血压变化,高胰岛素血症和氧化 (NO) 可用性.
主要方法:
- 11名男性接受了为期3周的干预:低脂肪,高纤维饮食,每天运动45-60分钟.
- 测量包括血压,禁食脂质,胰岛素,葡萄糖,氧化应激标志物 (8-异芽素F(2alpha) 和尿液中氧化物代谢物 (NO(X)).
主要成果:
- 显著降低了静缩和静缩血压,8 - 异芽素F ((2α)) 和禁食胰岛素.
- 尿中NO (X) 排泄的增加,表明NO的生物可用性有所改善.
- 脂质样本和体重的改善,尽管肥胖仍然存在.
结论:
- 一个简短的,密集的饮食和运动计划在3周内显著改善了心血管风险因素.
- 该干预措施显示出缓解动脉样硬化进展和相关临床问题的潜力.
- NO可用性的改善与胰岛素水平降低相关.
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