在内脏肥胖症中的交感神经激活
Guy E Alvarez1, Stacy D Beske, Tasha P Ballard
1Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216, USA.
Circulation
|November 13, 2002
概括
肌肉交感神经活动 (MSNA) 在增加腹部内脏脂肪的男性中较高. 这种内脏脂肪储存将肥胖与交感神经激活联系起来,可能会影响心血管疾病风险.
科学领域:
- 身体生理学 身体生理学
- 心血管健康 心血管健康
- 肥胖问题研究研究
背景情况:
- 众所周知,肌肉交感神经活动 (MSNA) 在肥胖个体中会升高.
- 腹部内脏脂肪在这种升高中的特定作用以前没有被研究过.
- 这项研究旨在探索男性内脏脂肪和MSNA之间的联系.
研究的目的:
- 测试MSNA在与腹部内脏脂肪水平较低的男性相比,腹部内脏脂肪水平较高的男性中增加的假设.
- 确定腹部内脏脂肪是否是将肥胖与MSNA升高联系起来的关键因素.
- 调查对心血管疾病风险的影响.
主要方法:
- 在37名久坐不动的男性中使用微神经图测量MSNA.
- 通过双能X射线吸收计评估身体成分.
- 使用计算机断层扫描量化腹部内脏和皮下脂肪.
主要成果:
- 与腹部内脏脂肪较高的男性相比,与腹部内脏脂肪较低的男性相比,腹部内脏脂肪较高的男性显示出大约55%的MSNA.
- MSNA显示,与腹部内脏脂肪 (r=0.65) 的相关性比与全体脂肪 (r=0.323) 或腹部皮下脂肪 (r=0.27) 的相关性更强.
- 即使考虑了总体脂肪,MSNA和内脏脂肪之间的关联仍然很重要.
结论:
- 在患有内脏肥胖症的男性中,MSNA水平升高.
- 腹部内脏脂肪作为一个重要的脂肪组织储存,将肥胖与人类的交感神经激活联系起来.
- 这些发现表明,一种机制导致了内脏肥胖患者中观察到的心血管疾病风险增加.
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