逆心室重塑可以减少缺血性腹反:在跳动的心脏中应用回声引导装置
Judy Hung1, J Luis Guerrero, Mark D Handschumacher
1Cardiac Ultrasound Laboratory and Surgical Cardiovascular Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA.
Circulation
|November 13, 2002
概括
在羊群中,通过心声学指导的乳头肌肉 (PMs) 重定位有效地减少了缺血性腹反 (MR). 这种新的技术改善了MR,而不会对左心室 (LV) 功能产生负面影响,提供了一种新的治疗方法.
科学领域:
- 心血管科学 心血管科学
- 医疗器械 医疗器械
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 缺血性额回 (MR) 涉及由于心室重塑和乳头肌肉 (PM) 位移而受到限制的叶片闭合.
- 目前的治疗方法,如戒指解环整形,是有限的,因为它们不能解决PM位移.
- 对于MR治疗的PM重新定位的有效性仍然不确定.
研究的目的:
- 测试这样的假设,即使用外部设备进行心声回声指导的PM重新定位可以减少MR.
- 评估这种技术是否会影响左心室 (LV) 功能.
- 在一个跳动的心脏模型中评估这种方法的可行性.
主要方法:
- 10只患有诱导性缺血性MR的绵羊使用外部Dacron贴片与充气气球在心声回声指导下进行PM重新定位.
- 3D回声心脏学评估了 mitra 门的几何形状.
- 声微仪,米勒导管和微球评估了LV功能和冠状动脉流量.
主要成果:
- 以回声引导的PM重新定位显著减少了PM绑定距离.
- 中度MR在手术后得到解决.
- 左心室收缩率和末端透气压力保持不变,冠状动脉流向非心脏病发作区域的流量没有减少.
结论:
- 一个用于PM重定位的外部设备可以成功地减少缺血性MR.
- 该技术不会影响LV功能.
- 这种简单的,回声引导的方法适用于心跳的心脏设置.
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