Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction01:26

Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

4.0K
α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.
4.0K
Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

Alkylation of β-Diester Enolates: Malonic Ester Synthesis

4.1K
Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
4.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Leveraging HIV-Specific CAR T Cells and Rapamycin Treatment in "Kick-and-Kill" HIV Cure Approaches.

bioRxiv : the preprint server for biology·2026
Same author

OSU-ERβ-12: a promising pre-clinical candidate selective estrogen receptor beta agonist.

Scientific reports·2025
Same author

<i>In Vivo</i> mRNA Delivery to the Lung Vascular Endothelium by Dicationic Charge-Altering Releasable Transporters.

Journal of the American Chemical Society·2025
Same author

Correlations among quantitative assays that measure the size of HIV reservoirs in people with HIV receiving antiretroviral therapy.

AIDS (London, England)·2025
Same author

Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells.

Nature communications·2025
Same author

Zidesamtinib Selective Targeting of Diverse ROS1 Drug-Resistant Mutations.

Molecular cancer therapeutics·2025

相关实验视频

Updated: Jan 13, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

3.4K

一种新且极强效的布里奥斯塔丁类似剂的实用合成.

Paul A Wender1, Jeremy L Baryza, Chad E Bennett

  • 1Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. wenderp@stanford.edu

Journal of the American Chemical Society
|November 15, 2002
PubMed
概括

一种新的布里奥斯塔丁1类似物,Macrocycle 1,在体外显示出对癌细胞的效果明显更高. 化学合成允许临床生产,将Macrocycle 1定位为一个有前途的新癌症治疗.

更多相关视频

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
09:10

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Published on: January 7, 2022

2.7K
Synthesis of 1,2-Azaborines and the Preparation of Their Protein Complexes with T4 Lysozyme Mutants
08:56

Synthesis of 1,2-Azaborines and the Preparation of Their Protein Complexes with T4 Lysozyme Mutants

Published on: March 25, 2017

8.0K

相关实验视频

Last Updated: Jan 13, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

3.4K
Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth
09:10

Synthesis of Masarimycin, a Small Molecule Inhibitor of Gram-Positive Bacterial Growth

Published on: January 7, 2022

2.7K
Synthesis of 1,2-Azaborines and the Preparation of Their Protein Complexes with T4 Lysozyme Mutants
08:56

Synthesis of 1,2-Azaborines and the Preparation of Their Protein Complexes with T4 Lysozyme Mutants

Published on: March 25, 2017

8.0K

科学领域:

  • 药用化学 医学化学
  • 在瘤学瘤学.
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 布里奥斯塔丁1是一种有前途的抗癌剂.
  • 目前的布里奥斯塔丁类型需要进一步开发以获得临床应用.

研究的目的:

  • 开发一种强效的布里奥斯塔丁类似剂 1.
  • 建立一种合成途径,用于临床生产新的类似物.

主要方法:

  • 在体外对人类癌症细胞系进行检测.
  • 评估蛋白质激酶C (PKC) 的亲和力.
  • 宏观循环的化学合成 1.

主要成果:

  • 宏循环1证明了对PKC的皮科莫尔亲和力.
  • 宏循环1表现出比布里奥斯塔丁1的100倍以上的功效.
  • 一种19步合成 (LLS) 产生了临床相关量的宏循环1.

结论:

  • 宏循环1是一种非常强大的布里奥斯塔丁1模拟剂.
  • 宏观循环1代表了癌症治疗的可行的临床候选人.
  • 高效的化学合成支持潜在的临床开发.