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针对维生素D受体的风湿症相关突变体的选择性激动剂的基于结构的设计

Steve L Swann1, Joel Bergh, Mary C Farach-Carson

  • 1Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.

Journal of the American Chemical Society
|November 15, 2002
PubMed
概括

新的非类固醇维生素D受体 (VDR) 类似物有效治疗导致人类维生素D耐药性狂犬病 (hVDRR) 的VDR突变. 这些化合物显示出对核VDR的高强度和选择性,提供了一个有前途的治疗策略.

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