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迪皮龙和农细胞:有什么风险?

Jayne E Edwards1, Henry J McQuay

  • 1Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital NHS Trust, The Churchill, OX3 7LJ, Oxford, UK. jayne.edwards@pru.oxa.c.uk

Lancet (London, England)
|November 16, 2002
PubMed
概括

No abstract available in PubMed .

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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