C-反应蛋白,动脉内皮激活和移植冠状动脉疾病的发展:一项前性研究
Carlos A Labarrere1, Joshua B Lee, David R Nelson
1Methodist Research Institute, Clarian Health Partners, Methodist, Indiana University, Riley Hospitals, Indianapolis, IN 46202, USA. clabarrere@clarian.org
Lancet (London, England)
|November 16, 2002
概括
C-反应蛋白 (CRP) 预测了移植冠状动脉疾病. 早期的CRP水平与ICAM-1表达相关,表明心脏移植受体患冠状动脉疾病,移植失败和缺血事件的风险较高.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 细胞间粘附分子-1 (ICAM-1) 表达和血清水平升高与移植冠状动脉疾病有关.
- 众所周知,C反应蛋白 (CRP) 能够刺激ICAM-1.
研究的目的:
- 调查C反应蛋白 (CRP) 和ICAM-1度之间的关联.
- 确定CRP是否与心脏移植后冠状动脉疾病的发展有关.
主要方法:
- 在心脏移植后3个月内,三明治ELISA测量了109名心脏移植患者的连续血清样本中的CRP和可溶性ICAM-1.
- 免疫组织化学评估了动脉内皮细胞ICAM-1在内心肌活检样本中.
- 冠状动脉图评估了冠状动脉疾病的发展,严重程度和进展.
主要成果:
- 在升高的CRP和动脉内皮细胞ICAM-1表达之间发现了显著的相关性 (p=0.001).
- 观察到CRP和可溶性ICAM-1度在移植后早期之间存在显著的关系 (p=0.003).
- 早期升高的CRP与冠状动脉疾病的发展相关 (p=0.004),严重程度增加 (p=0.02),进展 (p=0.01),缺血事件 (p=0.049) 和移植失败 (p=0.04).
结论:
- C-反应蛋白 (CRP) 水平可以识别心脏移植患者的冠状动脉疾病和移植失败的高风险.
- 针对CRP减少的治疗策略可能会改善患者的治疗结果.
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