代谢综合征的上皮层,自主和炎症原因:嵌套病例对照研究
E J Brunner1, H Hemingway, B R Walker
1International Centre for Health and Society, Department of Epidemiology and Public Health, University College London, England. e.brunner@ucl.ac.uk
Circulation
|November 20, 2002
概括
代谢综合征 (MS) 与激活的神经内分泌应激轴和心脏自主功能障碍有关. 这些变化似乎是可逆的,这表明慢性压力可能导致MS.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 心理神经免疫学 心理神经免疫学
背景情况:
- 代谢综合征 (MS) 可能是冠状动脉疾病的前身,但其原因尚不清楚.
- 这项研究调查了神经内分泌和心脏自主活动 (CAA) 在MS发展中的作用.
- 还研究了心理社会和行为因素对这些适应的影响.
研究的目的:
- 确定神经内分泌干扰和CAA是否有助于代谢综合征.
- 评估这些变化的可逆性.
- 探索心理社会和行为因素在与MS相关的神经内分泌适应中的作用.
主要方法:
- 这是一项双盲病例对照研究,将30例多发性硬化病例与来自怀特霍尔II队列的153名健康男性 (45-63岁) 进行了比较.
- 测量包括皮质醇分泌,灵敏度,24小时代谢物和类甲醇胺输出,以及通过心率变化 (HRV) 的心脏自主活性 (CAA).
- 进行了心理社会和行为因素的分析.
主要成果:
- 多发性硬化症患者表现出更高的皮质醇代谢物和甲氨酸产量,以及炎症标志物 (IL-6,CRP) 的升高.
- 病例显示较低的HRV,表明心脏交感主导.
- 在以前的MS病例中,神经内分泌标志物正常化,心理社会因素部分解释了MS和神经内分泌变化之间的联系.
结论:
- 代谢综合征与激活的神经内分泌应激轴和心交感主导相关.
- 这些神经内分泌变化似乎是可逆的.
- 慢性压力被认为是多发性硬化症的潜在原因,这需要进一步的前性研究.
更多相关视频
相关概念视频
01:31Hormones of the Adrenal Glands
5.8K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
5.8K
01:27Adrenal Gland Disorders
3.6K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.6K
01:30Coronary Artery Disease I: Introduction
1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
01:26Cushing Syndrome I: Introduction
16
Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the...
16
01:19Cushing Syndrome II: Pathophysiology
9
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
9
01:26Type II Diabetes I: Introduction
8
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
8