酸促进的DNA分裂活动和瓦拉辛C的总合成

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Updated: Aug 2, 2026

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
12:19

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

Published on: November 10, 2016

Alex H F Lee1, Jian Chen, Dongsheng Liu

  • 1Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

Journal of the American Chemical Society
|November 21, 2002
PubMed
概括

科学家们首次实现了抗生素瓦拉C的全合成,该化合物表现出强烈的抗瘤作用,并在酸性环境中有效地分裂DNA.

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During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
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