催化分子内烯插入到碳-碳单键中
Masahiro Murakami1, Tamon Itahashi, Yoshihiko Ito
1Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Yoshida, Kyoto 606-8501, Japan. murakami@sbchem.kyoto-u.ac.jp
Journal of the American Chemical Society
|November 21, 2002
概括
这项研究表明,在循环布坦中,催化分子内C-C键的形成. 一个阴离子(I) -dppp复合物促进了C-C双键的插入到C-C单键中,产生复杂的多环结构.
科学领域:
- 有机化学 有机化学
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
背景情况:
- 循环布坦衍生物是多功能合成中间体.
- 催化反应为C-C键形成提供了独特的途径.
- 配体选择显著影响催化活性和选择性.
研究的目的:
- 为了实现分子内C-C双键插入到一个C-C单键在循环butanone框架内.
- 探索罗催化反应在循环butanones的区域选择性.
- 为了研究不同素配体 (dppp与dppe) 对反应结果的影响.
主要方法:
- 用一种催化剂的量,处理一个3-(o-styryl) cyclobutanone的阴离子(I) -dppp复合物.
- 对反应中间体的分析,包括罗插入和迁移插入.
- 使用 ((I) -dppe复合物的比较研究来评估连接体效应.
主要成果:
- 通过使用 ((I) -dppp复合物的分子内C-C键形成,成功合成了二环[3.2.1]octan-3-one.
- 在碳-α-碳键中观察的插入.
- 发现环开放的α,β不和基与 (I) -dppe复合物的形成,表明改变了区域选择性.
结论:
- 阴离子 ((I) 复合物可以催化循环butanones中的分子内C-C键的形成.
- 选择素连接体 (dppp与dppe) 决定了C-C键裂解的区域选择性和产生的产品结构.
- 这项工作为构建复杂的多环基提供了一种新的方法,并突出了连接物控制在催化中的作用.
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