相关实验视频
Updated: Jul 18, 2026
10:08
Fabrication of Large-area Free-standing Ultrathin Polymer Films
Published on: June 3, 2015
通过逐层沉积可降解的多电解质来构建可水解降解的薄膜
Eduardo Vázquez1, David M Dewitt, Paula T Hammond
1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Journal of the American Chemical Society
|November 21, 2002
概括
研究人员为控制释放应用创造了薄,可降解的薄膜. 这些多层结构可以在生理条件下提供像DNA这样的功能分子.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 聚合物化学 聚合物化学
背景情况:
- 多层薄膜为各种应用提供可调节的特性.
- 控制释放系统对于药物输送和诊断至关重要.
- 可降解的聚合物提供了环保和生物相容的解决方案.
研究的目的:
- 通过层次沉积构建可水解降解的多层薄膜.
- 调查聚和聚离子在薄膜结构和释放中的双重作用.
- 评估这些薄膜是否适合控制释放功能性聚离子,如DNA.
主要方法:
- 可降解的多聚和多聚的层层沉积.
- 制造多层薄膜,厚度在10至100纳米之间.
- 在生理条件下的薄膜侵蚀和释放特征的评估.
主要成果:
- 成功构建了水解可降解的多层薄膜.
- 在生理条件下,经过控制的薄膜侵蚀.
- 证实了这些片能够结合和释放像DNA这样的功能性多离子.
结论:
- 通过层次组装,可以制造出水解可降解的多层薄膜.
- 这些薄膜表现出受控的侵蚀,并且适合释放功能性聚离子.
- 开发的系统有望用于先进的药物输送和生物材料应用.
相关概念视频
04:01Factors Affecting Solubility
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
01:09Colloidal precipitates
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...