多中心动脉瘤查研究 (MASS) 研究腹腔大动脉瘤查对男性死亡率的影响:一项随机对照试验
H A Ashton1, M J Buxton, N E Day
1John Radcliffe Hospital, Oxford.
Lancet (London, England)
|November 22, 2002
概括
对腹腔大动脉动脉瘤的超声波查显著降低了42%的死亡率. 这项大型研究证实了早期检测和干预腹腔大动脉瘤的好处.
科学领域:
- 血管外科 血管外科
- 公共卫生查 公共卫生查
- 诊断成像 诊断成像 诊断成像
背景情况:
- 关于对腹腔大动脉动脉瘤的超声波查的临床价值存在争议.
- 多中心动脉瘤查研究的目的是最终评估查的益处.
研究的目的:
- 评估超声波查在减少腹腔大动脉动脉瘤死亡率方面的有效性.
- 为腹腔大动脉动脉瘤查计划提供基于证据的建议.
主要方法:
- 基于人口的67,800名65-74岁的男性队列被随机分类.
- 参与者被邀请进行查或被分配到对照组.
- 随访包括重复超声波,死亡率数据和生活质量评估.
主要成果:
- 查邀请的接受率为80%,检测到1333个动脉瘤.
- 在受邀组中,动脉瘤相关死亡率为0.19%,对照组为0.33% (42%的风险降低).
- 出席查减少了53%的死亡率;30天外科手术死亡率为6% (可选) 和37% (紧急).
结论:
- 对腹腔大动脉动脉瘤的超声波查提供了可靠的益处证据.
- 查导致动脉瘤相关死亡率显著降低.
- 通过查进行早期检测可以改善患者的治疗结果.
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