怀孕期间发烧和胎儿死亡风险:一个队列研究
Anne-Marie Nybo Andersen1, Pernille Vastrup, Jan Wohlfahrt
1Department of Epidemiology Research, Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark. a.nybo@socmed.ku.dk
Lancet (London, England)
|November 22, 2002
概括
怀孕早期发烧不会增加胎儿死亡的风险. 这项大规模的丹麦研究发现,母体发烧与流产或死产之间没有联系,即使发烧的严重程度或时间不同.
科学领域:
- 生殖健康 生殖健康
- 产科 产科 产科 产科 产科
- 甲状腺学 甲状腺学
背景情况:
- 热量过高是已知的动物原体,可能导致胎儿再吸收和死亡.
- 人类怀孕期间的发烧,特别是在胚胎发生过程中,被怀疑是胎儿死亡的危险因素.
研究的目的:
- 调查怀孕早期母亲发烧与胎儿死亡风险之间的联系.
- 为了确定怀孕前16周的发烧是否会影响怀孕的结果.
主要方法:
- 在丹麦国家出生队列研究中对24,040名孕妇进行了大型队列研究.
- 在怀孕前16周内通过采访收集有关发烧事件 (温度,持续时间,时间) 的数据.
- 通过与国家登记册的联系确定了怀孕结果;使用考克斯回归分析.
主要成果:
- 18.5%的女性在前16周报告至少一次发烧发作.
- 在母亲发烧和胎儿死亡之间没有发现统计学意义上的关联 (RR 0.95;95% CI 0.80-1.13).
- 这种缺乏关联在不同的发烧特征和妊娠年龄,以及所有三个月的胎儿死亡中保持一致.
结论:
- 没有证据表明,怀孕前16周的发烧会增加胎儿死亡的风险.
- 这些发现表明,临床认可的怀孕并没有由于怀孕早期发烧而面临更高的胎儿死亡风险.
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