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Updated: Jul 9, 2026

Vampiric Isolation of Extracellular Fluid from Caenorhabditis elegans
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Vampiric Isolation of Extracellular Fluid from Caenorhabditis elegans

Published on: March 19, 2012

在Caenorhabditis elegans中,AIF介导的亡性DNA降解的机制

Xiaochen Wang1, Chonglin Yang, Jijie Chai

  • 1Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

Science (New York, N.Y.)
|November 26, 2002
PubMed
概括

诱导亡因子 (AIF) 和内核酶G (EndoG) 在线粒体启动的DNA降解途径中进行合作. 这种保存的途径对于编程细胞死亡至关重要.

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...