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在模拟显示,有限分散的复制器向更高的效率和保真度进化

Péter Szabó¹, István Scheuring, Tamás Czárán

¹Department of Plant Taxonomy and Ecology, Research Group of Ecology and Theoretical Biology, Eötvös University, 1/c Pázmány P. sétány, H-1117 Budapest, Hungary.

|November 26, 2002

概括

功能复制对于生命的起源至关重要. 矿物表面促进了RNA复制酶功能的进化,改善了复制速度和准确性,尽管有分子寄生虫.

科学领域:

生命的起源研究生命的起源研究
分子进化分子进化
益生菌化学益生菌化学

背景情况:

具有复制酶功能的催化RNA酶 (核糖酶) 被假设为生命起源的必要条件.
复制器的忠实性至关重要,因为在自然选择下,突变负载限制了模板长度.
较长的分子通常是更好的复制品,但这与忠实性约束相冲突.

研究的目的:

调查在哪些条件下更高效的复制品可以出现和传播.
探索矿物表面在促进RNA复制进化的作用.
了解复制真实性,速度和模板效率如何共同发展.

主要方法:

对复制器动态的数学分析.
细胞自动机模拟矿物表面上的益生菌复制.
模拟分子寄生虫和互惠利他主义的影响.

主要成果:

有效的复制物可以在被吸附到 prebiotic 矿物表面时传播.
观察到复制效率,复制速度和模板效率的进化性增加.
在矿物表面的相互利他主义 ("物种内部互惠主义") 抵消了分子寄生虫的负面影响.

结论:

益生菌矿物表面为RNA复制酶功能的逐步改善提供了一个合理的环境.
速度,忠诚度和效率的共同进化是通过表面介导的互惠主义来实现的.
这项研究支持了早期生命在矿物质基板上演变的假设.

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