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虚拟查,以检测 fenylalanine 类似物与 fenylalanyl-tRNA 合成酶的结合

Pin Wang1, Nagarajan Vaidehi, David A Tirrell

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Journal of the American Chemical Society
|November 28, 2002
PubMed
概括

这项研究介绍了HierDock,这是一种计算方法,可以预测 fenylalanine 类似物与 fenylalanyl-tRNA 合成酶 (PheRS) 的结合程度. 这种工具有助于虚拟选氨基酸类似物,节省了蛋白质工程研究的时间和资源.

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