血泌尿素在人类心脏系统性衰竭中的作用
Leong L Ng1, Ian Loke, Russell J O'Brien
1Department of Medicine and Therapeutics, University of Leicester, Leicester, UK. lln1@le.ac.uk
Circulation
|December 4, 2002
概括
血泌尿素II (UTN) 在心力衰竭 (HF) 患者中升高,可以作为诊断生物标志物. UTN水平不受年龄,性别或心力衰竭严重程度的影响,与N-终端亲脑尿性 (N-BNP) 不同.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 生物标志物发现发现
背景情况:
- 人类尿素II (UTN) 通过GPR14受体表现出强大的血管活性和心脏刺激作用.
- 心肌UTN表达在心力衰竭 (HF) 中增加,刺激尿酸的产生.
- 这项研究比较了HF患者的血UTN水平与N-终端脑前性尿素 (N-BNP).
研究的目的:
- 为了研究心力衰竭 (HF) 患者的血UTN水平.
- 为了比较血UTN水平与HF诊断中的N-BNP.
- 评估血UTN与年龄,性别和HF严重程度 (NYHA类) 的关系.
主要方法:
- 来自126名高风患者和220名对照组的血样本被分析为N-BNP和UTN.
- 统计分析包括相关性,回归和接收器运行特征 (ROC) 曲线分析.
- 我们对UTN和N-BNP之间的诊断性能进行了对HF和NYHA类的比较.
主要成果:
- 与对照组相比,HF患者的N-BNP和UTN水平都显著升高.
- 血UTN水平与N-BNP相关 (r(s) =0.35,P<0.001). 血UTN水平与N-BNP相关 (r(s) =0.35,P<0.001).
- 与N-BNP不同,血UTN与年龄,性别或NYHA类没有相关性;UTN表现出强大的HF诊断性能 (AUC=0.86) 并优于早期HF诊断 (NYHA类I).
结论:
- 在HF中血UTN升高表明病理生理学作用.
- 血UTN是一种潜在的替代生物标志物用于HF诊断.
- UTN的诊断实用性独立于患者的人口统计和HF严重程度.
更多相关视频
06:00Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
Published on: March 17, 2023
05:57The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
Published on: May 17, 2024
相关概念视频
Heart Failure Drugs: Diuretics
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Liver Physiology
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
Physiology of Urine Formation
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
Heart Failure II: Pathophysiology
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure VI: Adjunct Therapies
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
