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Updated: Jul 7, 2026

Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
14:27

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Published on: August 19, 2013

在 silico 中探索核酸酶催化:对酶结合基质和过渡状态的分子动力学研究

Devleena Mazumder1, Thomas C Bruice

  • 1Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA.

Journal of the American Chemical Society
|December 6, 2002
PubMed
概括

分子动力学模拟显示Tyr229,而不是His241,作为 inosine-uridine核酸酸酶的质子源. 他的241Ala突变破坏了这个关键的结网络,减少了酶活性.

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