基于性记忆概念的动态键组件的选择性形成
Tsutomu Ishi-I1, Mercedes Crego-Calama, Peter Timmerman
1Laboratory of Supramolecular Chemistry and Technology, MESA(+) Research Institute, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Journal of the American Chemical Society
|December 6, 2002
概括
研究人员使用Achiral组件创建了一个性超分子组件. 这种动态的非共价双色球组件表现出高动力稳定性,并记住了性,为新性材料铺平了道路.
科学领域:
- 超分子化学 超分子化学
- 有机化学 有机化学
- 材料科学 材料科学 材料科学
背景情况:
- 动态非共价组件提供可调节的特性.
- 在超分子结构中从无基质的构建块中实现奇拉性是具有挑战性的.
- 基于calixarene的组件对分子识别有希望.
研究的目的:
- 报告一个动态非共价双色球组件的enantioselective形成.
- 为了研究与性二糖酸的立体选择性相互作用.
- 为了证明在切拉性诱导器被移除后,组件中的性"记忆".
主要方法:
- 合成2-pyridylcalix[4]arene二胺胺胺 (1a) 和丁酸 (BuCYA).
- 1a(3) 的复杂化 (BuCYA) ((6) 与奇拉性二酸 (3a-e) 相结合.
- 使用光谱学方法分析二聚体和反聚体过量.
- 通过种族化实验进行动力稳定性研究.
主要成果:
- 形成一个动态的非共价双色球组件组件1a(3). (CYA) 的6.6).
- 光学活性组件 (P-或M-) 1a(3). (CYA) ((6) 是由合性二酸性诱导的.
- 在 diastereomeric 组件的形成中实现了90%的 diastereomeric 过剩.
- 证明了奇拉性"记忆":切拉性二酸L-3a的去除导致了光学活性组件 (M) - 1a). (BuCYA) ((6) 具有90%的反体过剩.
- 合组件表现出高动力稳定性,其半衰期在20°C下大约为一周.
结论:
- 嵌合体超分子组件可以从嵌合体组件中以enantioselective方式形成.
- 开发出来的组件表现出一种非凡的"记忆" - - 奇拉性.
- 它的高动力稳定性表明其在性传感或催化中的潜在应用.
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