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相关概念视频

Murine Nasal Lavage Fluid Collection without Blood Contamination05:12

Murine Nasal Lavage Fluid Collection without Blood Contamination

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The present protocol describes a novel method for avoiding blood contamination in murine nasal lavage fluid (NLF). Since this method ensures the NLF collection without blood contamination, it allows for more accurate detections of immunological components and various respiratory...
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Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome03:40

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OSTSS leads to pooled inflammatory mediators in the tear film, causing symptoms like epiphora and discomfort. Here, we present a case where therapeutic nasolacrimal lavage every 2 months resolved epiphora and itchiness, suggesting its efficacy as a therapeutic intervention for OSTSS. Additionally, we report subjective improvements in symptoms in 3 additional...
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Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment04:35

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

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Saline nasal lavage can be used to sample the canine nasal immune microenvironment. Because the approach is relatively non-invasive and does not disrupt the nasal tissues, it can be performed serially. Cells and proteins collected from the nasal lavage technique can be processed for various laboratory analyses.
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber08:47

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A protocol for conducting a challenge in an allergen exposure chamber (AEC) facility is presented. AECs have proven to be safe and effective tools for the induction of allergic symptoms or as an endpoint in the efficacy testing of allergen immunotherapy due to their ability to maintain stable particle concentrations and environmental...
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Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

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Batrachochytrium dendrobatidis infection in amphibians can be eliminated using a reduced concentration (0.0025%) and shorter duration (five minute baths for six days) of itraconazole than is generally used. Less mortality and fewer negative side effects were observed using this modified treatment...
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A method to intranasally administer drugs to awake mice for the purpose of targeting the brain is described. This method allows for repeat dosing over long periods using intranasal administration of drug without anesthesia, and nose-to-brain delivery with minimal systemic...
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Updated: Jan 8, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
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Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

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低密度脂蛋白受体基因突变和心血管风险在大型遗传级联查人口中

Marina A W Umans-Eckenhausen1, Eric J G Sijbrands, John J P Kastelein

  • 1Department of Vascular Medicine, Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands.

Circulation
|December 11, 2002
PubMed
概括

家族性高胆固醇血症 (FH) LDL受体基因突变部分解释胆固醇水平和心血管疾病 (CVD) 风险. 其他遗传因素可能会影响FH患者的结果.

科学领域:

  • 遗传学 是一个遗传学.
  • 心血管医学 心血管医学
  • 脂质代谢 脂质代谢是什么

背景情况:

  • 家族性高胆固醇血症 (FH) 是一种遗传性疾病,其特征是高的LDL胆固醇.
  • 遗传级联查确定了患有FH的患者及其亲属,以研究疾病决定因素.
  • 心血管疾病 (CVD) 风险的评估与LDL受体基因突变有关.

研究的目的:

  • 研究不同LDL受体基因突变对脂蛋白水平的影响.
  • 确定这些突变对FH患者心血管疾病 (CVD) 风险的影响.
  • 确定FH中心血管疾病的潜在额外家族风险因素.

主要方法:

  • 分析了399名FH患者和未受影响的亲属的队列.
  • 进行了根据年龄,性别和家庭关系进行调整的多变量分析.
  • 根据突变类型,对LDL胆固醇,HDL胆固醇和心血管疾病发病率进行了比较.

主要成果:

  • 在不同的LDL受体突变中观察到LDL胆固醇水平的显著变化.
  • 零基因基因与较高的LDL胆固醇有关;N543H/2393del9突变显示的升高不那么严重.
  • 与亲属相比,FH患者患心血管疾病的风险明显高 (RR 8.54),N543H/2393del9突变显示相关风险较低.

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Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
04:35

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

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Intranasal Administration of CNS Therapeutics to Awake Mice
07:15

Intranasal Administration of CNS Therapeutics to Awake Mice

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结论:

  • LDL受体基因突变只能解释部分的LDL胆固醇变化和心血管疾病负担在FH.
  • 这项研究表明,存在未确定的家族风险因素影响FH中心血管疾病风险,可能独立于脂质水平.